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  • Insulin resistance

    Posted by ranakolankiewicz on November 29, 2022 at 5:43 pm
    Hi B. Can you please share what to look for to know if someone has insulin resistance? What are the expected numbers on tests like GTT, fasting insulin, fasting glucose, C peptide levels etc?
    Bernadette replied 1 year, 11 months ago 3 Members · 2 Replies
  • 2 Replies
  • Daniel

    Member
    November 29, 2022 at 8:05 pm

    Hey ,

    Fasting Insulin
    I usually consider fasting insulin between the 2-6 uIU/ml optimal. (The typical reference range is: 2-25)

    OGTT (Oral Glucose Tolerance Test)
    The glucose tolerance test (usually done with 75 gram of glucose – not with food) gives back a curve. 
    • The curve is optimal when blood sugars spike in the first 30-60 minutes and return to normal after 2-2.5 hours. The highest value should not exceed the renal threshold (160-180 mg/dl). This means basically there should be no glucose in the urine afterwards.
    • With early insulin resistance, we can see blood glucose drop after 2-2.5 hours below fasting levels. In this stage blood sugar levels can still appear normal, but there is already a more robust insulin response. In this stage, insulin is winning and blood glucose is dropping below fasting levels
    • In a more advanced stage, blood sugars rise less quickly (the blood sugar peaks between 1-1.5 hours). The highest blood sugar level exceeds the renal threshold.  The blood glucose level does not return to normal after 2.5 hours.

    Just remember that a blood glucose meter can make errors. With mild unclear values, you wouldn’t want to evaluate only one curve(Because glucose is a reflection of insulin). For that reason, I usually recommend doing an oral insulin tolerance test at the same time.

    for both these tests, make sure if patients are on a ketogenic diet they raise their carb intake for a minimum of 3 days.

    Fasting glucose
    I consider optimal likely between 80-88 mg/dl. Above is evidence of insulin resistance.

    C-peptide
    I consider optimal likely between 1-2 ng/ml (with a typical reference range of 1.0-4.2). 

    I hope this helps!

  • Bernadette

    Member
    November 30, 2022 at 4:05 am

    Hi  – you can also find all of these optimal ranges and additional information in the Blood Sugar Regulation course in the “Testing Considerations” video here.

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