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  • Different types of B12

    Posted by naslam1603 on February 4, 2023 at 9:36 pm
    Hi B. and Daniel,

    I notice there are different types of B12. Which one is better?

    1. Methylcobalamin
    2. Adenosylcobalamin
    3. And another I think

    I am taking this. 

    Daniel replied 1 year, 9 months ago 2 Members · 1 Reply
  • 1 Reply
  • Daniel

    Member
    February 5, 2023 at 1:14 pm

    Hey ,

    Thank you for uploading the ingredient list! With questions about supplements, this is really helpful!

    Crash course vitamin B12
    Yes, you are right.  Vitamin B12 comes in different forms. The best analogy I can think of is the analogy of a fashion show. Imagine you are a model from a fashion show. The clothes you carry, the way you look, it all depends on what type of show you need to walk for. If you are on a fashion show for bathing suits, you will wear different clothes and you will look different as for a fashion show for business suits.

    But beneath it all, there is only one person.

    The same you can say for vitamin B12. There are differences between the forms, but most forms can change into other forms. There is one exception in the four forms you will find in supplements.
    • Cyanocobalamin – This is a synthetic form of vitamin B12. It can be converted to other forms by the body. But the body doesn’t convert other forms to cyanocobalamin, because the body doesn’t use it. There are several why I (and others) usually won’t recommend cyanocobalamin. One of the reasons is that when the body converts this form of B12 to other forms of B12, a little bit of cyanide is formed. Obviously, this bit is so tiny it doesn’t lead to cyanide poisoning. But this is one of the reasons why some people (including me) don’t like to recommend cyanocobalamin so fast. Let me add a nuance here. If one could only use cyanocobalamin and there are serious B12 symptoms, I definitely would recommend cyanocobalamin. But in the presence of other options, I always recommend the other forms.
    • Hydroxocobalamin – This form is often used in vitamin B12 injections. But so is cyanocobalamin. It is also found in foods and can be used by the body to form adenosylcobalamin and methylcobalamin. It is used for first-line intervention with cyanide poisoning. 
    • Adenosylcobalamin – This form of vitamin B12 is mainly used by mitochondria. In the absence of adenosylcobalamin, the body produces Methylmalonic Acid or MMA for short. This is what is measured by doctors to see if your cells have sufficient vitamin B12.
    • Methylcobalamin – This form of vitamin B12 is used to form myeline sheets in nerves (together with folate). Methylcobalamin can be converted into adenosylcobalamin by the body. Methylcobalamin plays also a role in methylation. If methylation happens poorly, homocysteine can elevate. Sometimes homocysteine elevates by the absence of methylcobalamin, and sometimes there are genetic variations in the body, that can produce imbalances in the methylation process. Here are 2 examples related to vitamin B12.• The MTR gene works in the final step to regenerate homocysteine into methionine using methylcobalamin. Some variations in this gene can cause in some people slower working enzymes
    • The gene MTRR that codes for the enzyme Methionine synthase reductase regenerate the methylcobalamin for MTR to use again. There are variations known in this gene that causes the production of slower and faster enzymes as well.

    The main point is that different people might need different forms. There are many other genetic variations that can influence vitamin B12. Some affect the transport protein transcobalamin, some affect receptors for the uptake of vitamin B12.

    This can lead sometimes to that one form feeling better than the other form. But I would recommend just trying and feeling how your body responds. 

    The forms I mostly recommend myself are Methylcobalamin (since it converts to adenosylcobalamin) and a mixture of methylcobalamin and adenosylcobalamin.

    I hope this helps.

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