• Lab Tests, Markers & Interpretations

  DNA testing results

  Posted by yasminatassi on June 27, 2024 at 12:33 pm

  Hello B

  a few months ago I had DNA testing done and I attach the results here. I would love to hear your advice and guidelines on supplements I should take as prevention . Am particularly concerned about the MTHFR and COMT and want to know the best way to optimize against the genetics i have been given . ( my mother was diagnosed with ovarian cancer at 49 and died at 51). Am assuming it also reflects my acne issues

  Am also concerned About bone density mutation as you know I above quiet a bit of shoulder joint pain

   

  

   

  

  Daniel replied 6 months, 3 weeks ago 2 Members · 1 Reply
• 1 Reply

• 

  Daniel

  Member

  June 27, 2024 at 7:53 pm

  Hey @Yasmin atassi,

  Gene tests are great! They can provide you with insights into your unique strengths and weaknesses. That being said, it’s good to be aware that not even if you have a faster or slower working enzyme because your genetic code is slightly different, it doesn’t mean it determines health outcomes only. What you eat, what you do, stress or shortly the environment in which you move plays a very big factor as well. And that’s good news!

  MTHFR/MTR
  These genes both play a role in the methylation cycle. Your MTR codes for a variation on an enzyme that works a bit more quickly than average, while your MTHFR is a little slower.

  What does that mean?
  In the methylation cycle methionine gets converted to homocysteine and back. The enzyme that codes for MTR will speed up the step before making methionine, while the MTHR gene, which helps the conversion of methionine to homocysteine is slowed down. Does this mean your methylation cycle is unbalanced? I don’t know. Measuring values like homocysteine can provide more insight into the actual balance.

  If you use a vitamin supplement with B vitamins, you want to ensure you use a methylated version of folate (methyl-folate).

  COMT
  COMT helps breakdown dopamine, adrenaline and also estrogen. The variation your gene encodes for produces an enzyme that works a little slower. Again, this doesn’t say anything about your balance. Symptom-wise, when you’re experiencing estrogen dominance symptoms, adding a magnesium supplement can help since magnesium is needed for the enzyme to work.

  Here you can see a beautiful example where genes don’t determine everything. You could have the fastest COMT encoding gene, but if you’re magnesium deficient, you have functionally a slow-working COMT enzyme.

  Acne and your genes
  You’ve got some other gene variations that could influence your acne as well. The BC01 gene turns precursors of vitamin A found in plants into the bioactive form of vitamin A. Your variation works a little less efficiently. Therefore providing your diet with vitamin A from animal sources (for example liver) would be recommended. Vitamin A plays an important role in the skin and often helps improve acne symptoms.

  Some genes related to inflammation are a little slower as well. For example, the variation of the FADS1 gene which you carry, encodes for a slower-working enzyme. FADS1 is involved in the metabolism of omega 3 and omega 6 fatty acids. A slower working FADS1 is associated with higher inflammation. Is this the case with you? I don’t know. But adding Omega 3 in your diet is more important than for people with a faster working gene.

  The gene that helps breakdown lactose works slowly as well. Therefore lactose-rich products (like milk products) will create more inflammation in your unique case. A lactose-free diet will likely benefit you (and possibly reduce acne as well). For gluten, this DNA profile shows a similar story.

  Your vitamin D gene profile also shows a few variations. This means it’s harder for you to convert vitamin D to its bioactive form. This can be overcome by adding vitamin D to your diet, using a supplement or prioritising a walk in the sun. Magnesium is also an important nutrient since it helps to convert the precursors of vitamin D to its bioactive form as well.

  Vitamin D helps to reduce inflammation as well.

  In the detoxification section, you can see a deletion of a gene that is involved in detoxification (GSTM1 gene). This deletion doesn’t mean you can’t detoxify, however, a lifestyle that is low in toxins might be more beneficial to you than someone who has the GSTM1 gene.

  I hope this information helps you to make some educated choices!

Log In to Reply