Hey ,

There are several reasons why histamine can be elevated. The histamine can be produced by your body as a reaction from your immune system to antigens. Foods can be high in histamine and certain bacteria can produce histamine.

Since food can contribute to histamine it would be good to check if you were having by accident some high histamine foods before the test, so you can rule out that option. There is a handout here in the B Better library that can help you do that.

What is LPS?
LPS is short for lipopolysaccharide. When certain bacteria (gram-negative bacteria) in your microbiome die, they break down. LPS are found in the outer cell membrane of these bacteria. You can compare them with ‘bodyparts’ of dead bacteria.

When LPS are elevated in the blood, this means they passed through damaged parts of the gut lining (leaky gut as you called it).

New test vs old test
The good change on the new test is that your DAO enzymes went up, Are you using supplements containing DAO? If not, your body’s own production went up. Adding in B vitamins (B6 in particular) can have contributed to this. More DAO production can also be an indication that the mucosal integrity has been improved.

Also, your immune system seems to respond better. These changes are important to note as well.

What can you do?
• Remove histamine foods/foods that liberate histamine (see the mentioned handout) and food sensitivities. Quercetin supplements can help inhibit histamine from the immune system and help the gut lining (2x 500 mg daily is what I advise my clients often to start with). 
• Help repair the gut lining. Bone broth,  but also collagen which we recently talked about can help repair the gut lining.
• Omega 3’s (2-4 grams) and Extra Virgin Olive Oil high in polyphenols can help lower LPS and reduce inflammation.
• Vitamin C and copper are just like vitamin B6 cofactors for the production of the DAO enzyme. Getting these in can help you as well.
• Caprylic acid found in coconut oil and MCT oil can be helpful with yeast. There are more options here of course, but I would advise a gentle approach here since antimicrobials can potentially increase LPS.

I hope this helps!

,

I’m so sorry to hear about the burning feelings you are suffering with. I do believe the opinion of your gastroenterologist is important to find out if the medication isn’t working. At the moment, what kind of dosages of femotidine are you taking?

Obviously foods influence the burning sensation as well, but right now, did anything change? For example is the burning sensation at the same place? Do you feel the burning sensation continuously? If the pain changed, in what kind of time frame did it change?

 sorry to hear you’re still in so much pain. Did you end up creating that meal plan so we can help guide you in terms of diet? And did you have your neo emotional release session yet? Glad you’re getting mold checked out. Hope they’re proper mold inspectors and not just going to check AC ducts and do a visual inspection. Mycotoxins are invisible and odorless. Ask if they know about the ERMI test in the US to check mycotoxins.

DAO enzymes can help bring down histamine levels. I know that you do not want to consume pork but I have had Muslim clients consider it when it becomes their only option for their health. Perhaps discuss it with a sheikh?

 it works differently than Histamine Block but they are complementary. HistaminX helps modulate histamine levels through different mechanisms of action, while Histamine Block (the DAO enzyme) directly degrades histamine.

Quercetin for example in HistaminX is a natural anti-histamine that calms the immune system to reduce or prevent histamine release.

Stinging nettle also has ‘antihistamine’ action because it makes histamine receptors less sensitive. Because of this mode of action, I tend to use stinging nettle as a synergistic, additive pairing with an antihistamine like quercetin (vs. an agent on its own). 

HistaminX has both of these in the formula, among others.

Hey ,

I think like Bernadette is mentioning, that adding DAO enzymes would be worth a try. Vitamin C is also essential for the production of DAO enzymes. As mentioned above, you already produce more enzymes than on your previous Advanced Intestinal Barrier assessment. Your OAT however shows low vitamin C status.

Histamine Block does contain a little bit of vitamin C, but that might not be enough. Having more vitamin C might help the body optimize for DAO enzyme production as well.

Curcumin can help prevent mast cell activation (according to this article here). There is some evidence that compounds in ginger are just as effective as anti-histamine. You could try to add ginger or ginger tea as well if you can tolerate it.

 curcumin is an ingredient in tumeric often extracted as a supplement. But since it is from tumeric, fresh ginger might be a better choice for now!

Hey ,

Personally I have no experience with NATURDAO. But give it a try and see if you feel better with it!

With the use of vitamin C, start low and slow as well. Vitamin C or ascorbic acid as it is called is still acidic in nature.

You probably did, but just in case you didn’t, ask your doctor on how to come of famotidine. To come off famotidine is usually done by gradually reducing the dosage a period so that the stomach lining can adjust to the new acidity in the stomach.

To reach the conclusion your own DAO production went up, I just compared your recent test with your previous test. You can see that you are producing more enzymes right now. 

I can’t tell why your histamine was elevated just from the test, but besides other causes like SIBO, there might be elevations from food as well. If you could trace back what you had eaten and would conclude you have had histamine rich foods, this could lead to a better interpretation of the results.