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Thiamin (B1)
Hi B. & Daniel,There appears to be different types of B1. Mono nitrate and Hydrochloride.
Then what is Benfotiamine and TTFD. Are there other forms.
I was trying to locate the course explaining all different forms if B1 but unae to navigate my through it.
I read somewhere TTFD version can help with Gastroperisis.
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0 Replies
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Hey ,
Vitamin B1 has been shown to help with diabetic neuropathy. With neuropathy, the nerves get damaged and this can influence the speed of the emptying of the stomach.
The absorption of vitamin B1 works via transporters that are located in the gut lining. The vitamin B1 from food is freed by enzymes (intestinal alkaline phosphatases) but the rate-limiting step for absorption is determent by the saturation of these transporters.
The mononitrate and hydrochloride forms of B1 are salt forms and have a low bioavailability (between 3-6% according to this article). This has to do with the rate-limiting step I described earlier.
Benfotiamine is fat-soluble and as a result, it is much more bioavailable. Because it is fat-soluble there is some evidence it can cross the blood-brain barrier, but it is debated.
But the evidence for TTFD (Thiamine Tetrahydrofurfuryl Disulfide) to penetrate the blood-brain barrier is much stronger. The absorption isn’t as dependent on the transporters in the gut since it can travel through the cell membrane because of its chemical structure. It also has a high bioavailability. If you look for the benefits of the penetration of the blood-brain barrier, this form is the best one.
A clean TTFD supplement (free of binders and fillers) that I like is Thiamax from Objective Nutrients. It only contains a capsule.
I hope this information will make your choice easier.
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Thank you Sir. I will take a look into Thiamax. I am still taking B complex liquid at the moment.
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Mum has diabetic neurapthy. I could get her to try TTFD. I just looked at the vitamin patch I take and it contains Thiamin mononitrate.
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With neuropathy, it would also be a good idea to check her vitamin B12, folate and vitamin B6. A lack of these vitamins can also cause neuropathy.
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Sure thing
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Hi Daniel, could I take TTFD and the B complex to keep things in balance. Also, wanted to know whether there is any correlation between different minerals and Thiamin. For example, zinc needs to balance with copper and vice versa.
Thiamix, what dosage should I take please?
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Hey ,
Because TTFD isn’t depending on transporters, there isn’t a competition issue going on with the other B vitamins. With thiamine, you can dose between the 25 and 100 mg to correct for a mild deficiency.
When it comes to safety: dosing long-term for 300 mg didn’t show problems in studies with diabetic patients. The supplement I recommended comes in pills containing 100 mg. You can take it daily. With thiamine, no contraindications are known as well.
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Good morning Daniel, I’ve ordered the Thianix. Do you have personal experience with clients with this brand. I did come across a cream, but it was in the US.
Should I continue with the liquid version of B complex by metabolics?
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I wouldn’t stop it because I added TTFD. When it comes to continuing, that answer would be best answered on the basis of your serum levels. I would especially curious about your serum folate levels.
I don’t recommend TTFD often, but people who do use it often feel it influences their concentration positively. It is one of those supplements you can feel working.
The people I did recommend it often report that they feel more focused after an hour. I personally have the same experience. I also feel more focused in my workouts as well.
The pills are very small and are best consumed with meals for optimal absorption.
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I wanted to try TTFD to see if it helps with Gastroperisis. Regarding Folate, I’m not taking a separate folate. Just the B complex liquid.
The folate in in B complex liquid is 400ug. Is this sufficient?
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hard to say with 100 per cent accuracy without current data, but your folate measurement in February 2023 was 5.88 ug/l. That is in the lower half of the reference range. I know it went up after you started supplementing with B vitamins, but not by much.
A higher dose like 800ug for a few weeks is something you could try with such values. But again, without knowing current serum values, I wouldn’t know what to advise exactly.
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Thank you for the guidance. I’ll try to find a liquid version. I notice there is a liquid version by quick silver. It’s a pump mechanism.
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